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norskBlar i forfatter "Sundset, Rune"
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An Acylation-Finkelstein Approach to Radioiodination of Bioactives: The Role of Amide Group Anchimeric Assistance
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-02-28)Herein, we report a straightforward sequential acylation‐Finkelstein approach to achieve iodination of amine containing bioactives. The utility was demonstrated by successful radiolabelling with <sup>123</sup>I in high radiochemical yield. Moreover, microwave‐assisted Finkelstein reaction can be employed to enhance conversion and reaction rates to obtain the desired iodides. The method is of interest ... -
Cerebral blood flow measurements with 15O-water PET using a non-invasive machine-learning-derived arterial input function
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-02-08)<p>Cerebral blood flow (CBF) can be measured with dynamic positron emission tomography (PET) of <sup>15</sup>O-labeled water by using tracer kinetic modelling. However, for quantification of regional CBF, an arterial input function (AIF), obtained from arterial blood sampling, is required. In this work we evaluated a novel, non-invasive approach for input function prediction based on machine learning ... -
Diagnostic imaging and ionizing radiation exposure in a level 1 trauma centre population met with trauma team activation: a one-year patient record audit
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-02-15)This audit describes ionizing and non-ionizing diagnostic imaging at a regional trauma centre. All 144 patients (males 79.2%, median age 31 years) met with trauma team activation from 1 January 2015 to 31 December 2015 were included. We used data from electronic health records to identify all diagnostic imaging and report radiation exposure as dose area product (DAP) for conventional radiography ... -
Discovery of a lead brain-penetrating gonadotropin-releasing hormone receptor antagonist with saturable binding in brain
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-16)We report the synthesis, radiosynthesis and biological characterisation of two gonadotropin‐releasing hormone receptor (GnRH−R) antagonists with nanomolar binding affinity. A small library of GnRH−R antagonists was synthesised in 20–67 % overall yield with the aim of identifying a high‐affinity antagonist capable of crossing the blood–brain barrier. Binding affinity to rat GnRH−R was determined by ... -
Evaluation by metabolic profiling and in vitro autoradiography of two promising GnRH‐receptor ligands for brain SPECT imaging
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-18)The increased expression of gonadotropin releasing hormone receptor (GnRH‐R) in brain has been strongly linked to Alzheimer disease. Therefore, the development of radiolabeled imaging agents for GnRH‐R is relevant for early diagnosis of Alzheimer disease. We have recently disclosed the discovery of two promising compounds displaying nanomolar‐range affinity for the GnRH‐R. In the present study, a ... -
First in vivo evaluation of a potential SPECT brain radiotracer for the gonadotropin releasing hormone receptor
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-11-09)<p><i>Objectives</i>: In vivo evaluations of a gonadotropin releasing hormone-receptor single photon emission computed tomography radiotracer for non-invasive detection of gonadotropin releasing homone-receptors in brain.</p> <p><i>Results</i>: We have used a simple, robust and high-yielding procedure to radiolabel an alpha-halogenated bioactive compound with high radiochemical yield. Literature ... -
Glioblastoma PET/MRI: kinetic investigation of [<sup>18</sup>F]rhPSMA-7.3, [<sup>18</sup>F]FET and [<sup>18</sup>F]fluciclovine in an orthotopic mouse model of cancer
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-22)<b><p>Purpose</b> Glioblastoma multiforme (GBM) is the most common glioma and standard therapies can only slightly prolong the survival. Neo-vascularization is a potential target to image tumor microenvironment, as it defines its brain invasion. We investigate [<sup>18</sup>F]rhPSMA-7.3 with PET/MRI for quantitative imaging of neo-vascularization in GBM bearing mice and human tumor tissue and compare ... -
Injury coding in a national trauma registry: a one-year validation audit in a level 1 trauma centre
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-30)<i>Background</i> - Hospitals must improve patient safety and quality continuously. Clinical quality registries can drive such improvement. Trauma registries code injuries according to the Abbreviated Injury Scale (AIS) and benchmark outcomes based on the Injury Severity Score (ISS) and New ISS (NISS). The primary aim of this study was to validate the injury codes and severities registered in a ... -
Liposomes - Human phagocytes interplay in whole blood: effect of liposome design
(Journal article; Tidsskriftartikkel, 2023-10-20)Nanomedicine holds immense potential for therapeutic manipulation of phagocytic immune cells. However, in vitro studies often fail to accurately translate to the complex in vivo environment. To address this gap, we employed an ex vivo human whole-blood assay to evaluate liposome interactions with immune cells. We systematically varied liposome size, PEG-surface densities and sphingomyelin and ... -
Machine learning derived input-function in a dynamic 18F-FDG PET study of mice
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-13)Tracer kinetic modelling, based on dynamic <sup>18</sup>F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is used to quantify glucose metabolism in humans and animals. Knowledge of the arterial input-function (AIF) is required for such measurements. Our aim was to explore two non-invasive machine learning-based models, for AIF prediction in a small-animal dynamic FDG PET study. 7 tissue ... -
Ny diagnostikk for Alzheimers i Nytt Senter
(Chronicle; Kronikk, 2015-04-23) -
PET-CT in the-subarctic region of Norway 2010-2013. At the edge of what is possible?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-08-28)Background It is challenging to obtain a similar access to positron emission tomography/computed tomography (PET-CT) within the whole region served. In the subarctic and arctic region of Norway, significant distances, weather conditions and seasonable darkness have been challenging when the health care provider has aimed for a high quality PET-CT service with similar availability to all inhabitants. ... -
Quantitative PET/MR imaging of lung cancer in the presence of artifacts in the MR-based attenuation correction maps
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-13)<i>Background</i> - Positron emission tomography (PET)/magnetic resonance (MR) imaging may become increasingly important for assessing tumor therapy response. A prerequisite for quantitative PET/MR imaging is reliable and repeatable MR-based attenuation correction (AC).<p> <p><i>Purpose</i> - To investigate the frequency and test–retest reproducibility of artifacts in MR-AC maps in a lung cancer ... -
Small molecule piperazinyl-benzimidazole antagonists of the gonadotropin-releasing hormone (GnRH) receptor
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-08-14)In this communication, we report the synthesis and characterization of a library of small molecule antagonists of the human gonadotropin releasing hormone receptor based upon the 2-(4-<i>tert</i>-butylphenyl)-4-piperazinyl-benzimidazole scaffold <i>via</i> Cu-catalysed azide alkyne cycloaddition. Our main purpose was to find a more soluble compound based on the WAY207024 lead with nanomolar potency ... -
Unsupervised supervoxel-based lung tumor segmentation across patient scans in hybrid PET/MRI
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-29)Tumor segmentation is a crucial but difficult task in treatment planning and follow-up of cancerous patients. The challenge of automating the tumor segmentation has recently received a lot of attention, but the potential of utilizing hybrid positron emission tomography (PET)/magnetic resonance imaging (MRI), a novel and promising imaging modality in oncology, is still under-explored. Recent ...
